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The PI is responsible for submitting the request for a CoC to NIH or other federal agency following IRB approval. 1. A Certificate of Confidentiality can also be issued for non-.NIH funded research. Purpose. Certificates of Confidentiality (CoCs). -COC Application Form (you will complete a draft on the COC website and provide the IRB a PDF copy. Guidance on Certificates of Confidentiality. ➢ See the CoC user guide for details about the application process. Guidance on Certificates of Confidentiality. What is a Certificate of Confidentiality? NIH Policy Change Regarding Certificates of Confidentiality.