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A high volume of fluid can strongly reduce a drug's concentration in urine. Therefore, to detect diluted samples, the concentration of creatinine in urine is determined during testing drugs of abuse. If the concentration is below 20 mg creatinine/dl urine, the urine sample is usually rejected for drug testing.
Amphetamine (more on this below) and methamphetamine are the most commonly reported false positive.
When your urine specimen for a drug test comes up diluted, you drank too much water in advance of the test. You should be careful not to overconsume fluids prior to a drug test. An extra glass of water is about all you need. If you drink too many fluids, then you will more than likely end up with a diluted specimen.
Another way of expressing the normal range for test results is: 14 to 26 mg per kg of body mass per day for men (123.8 to 229.8 µmol/kg/day) 11 to 20 mg per kg of body mass per day for women (97.2 to 176.8 µmol/kg/day)
Urine, blood, breath, saliva, sweat, or hair samples may be used. Urine testing is most common because it is noninvasive, quick, and able to qualitatively detect a wide range of drugs. The window of detection depends on the frequency and amount of drug intake but is about 1 to 4 days for most drugs.