The Employee Stock Option Plan of Vivigen, Inc. is a corporate document that provides a structured framework for offering stock options to eligible employees. Designed to promote employee retention and company growth, this plan enables employees to purchase shares at a predetermined price based on their level of responsibility within the organization. Unlike simpler stock option agreements, this plan accommodates various employee levels, making it more comprehensive and beneficial for stakeholders.
This form should be utilized when a corporation, such as Vivigen, Inc., intends to implement a formal Employee Stock Option Plan. It is particularly relevant for companies aiming to attract and retain talented employees by providing them with ownership stakes. The plan should be established in compliance with federal securities regulations and could be referenced during mergers or corporate transactions.
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DBM Putty is composed of Demineralized Bone Matrix and sodium hyaluronate. The demineralized bone allograft in this product is prepared from tissue procured from a deceased donor using aseptic surgical techniques.Sodium hyaluronate is a naturally derived material that is biocompatible and biodegradable.
ViviGen is a Human Cells, Tissues, and Cellular and Tissue-based Product (HCT/P) comprised of cryopreserved viable, lineage committed bone cells within a corticocancellous bone matrix and demineralized bone delivering all three properties necessary for bone formation.
Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix.As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts; conversely the mechanical properties are significantly diminished.
Cellular bone matrices (CBM) are allograft products that provide three components essential to new bone formation: an osteoconductive scaffold, extracellular growth factors for cell proliferation and differentiation, and viable cells with osteogenic potential.
In order to determine the presence of viable cells, ViviGen bone chips were thawed after processing and cryopreservation and were plated in culture wells. The cells were able to migrate from the bone chips and attach to the culture plate demonstrating that they survived the freezing and thawing process1 (Figure 2).
ViviGen is a cellular allograft intended for repair or reconstruction of musculoskeletal defects. ViviGen is being utilized in fusion, nonunion, and malunion for foot/ankle or long bone trauma in patients with compromised biology.
2.1. Osteoblasts. Osteoblasts are cuboidal cells that are located along the bone surface comprising 46% of the total resident bone cells and are largely known for their bone forming function 22.