Title VII prohibits employment discrimination based on race, color, religion, sex and national origin. To combat workplace discrimination from an employer with at least 15 employees, you can file a discrimination charge with the EEOC.Discrimination on the Basis of Interracial Association. 319. For purposes of Title VII, race discrimination includes discrimination on the basis of the. 320. Title VII prohibits employment discrimination, including unlawful harassment based on sex. Second Circuit Court of Appeals Rules That Title VII Prohibits Sexual Orientation Discrimination. The statute was a landmark piece of legislation that protected workers from discrimination based on race, color, religion, sex and national origin. The Civil Rights Act of 1964 prohibited discrimination based on race, color, religion, sex, and national origin. Title VII of the Civil Rights Act of 1964 and the Pennsylvania Human Relations Act (PHRA) prohibit discrimination based upon an employee's national origin. Title VII of the federal Civil Rights Act of 1964.