Again, the most mathematically sound/reliable option is the 5th or 6th round, but you could make do with any decision, especially depending on the people you are drafting with.
At the bare minimum, you want to draft enough players to fill your starting lineup, so one QB, two RBs, two WRs, one TE, one kicker, and one DST. Then, you want at least one more RB, WR, or TE to fill that flex spot.
Standard rosters include one Quarterback (QB), two Running Backs (RB), two Wide Receivers (WR), one Tight End (TE), one Flex (RB/WR/TE), one Defense/Special Teams (D/ST), one Kicker (K) and seven Bench Spots (BE -- players on your roster who are not in your active lineup for a given week).
Ways to Join a League: Take part in a draft in the Live Draft Lobby. Choose a league to join using the League Directory. Accept an invitation by selecting a link from an emailed invitation.
Basically early is best, then late, then middle. That was done with last year's players, projections, & ADPs though.
Best Way to Draft Fantasy Football Know Your Rules (no kidding) ... Use Dynamic Player Valuations – Not Just RankingsDiscover why rankings change as you draft. Outsmart Your Competition By Understanding Positional ScarcityLearn why the highest-scoring player isn't the most valuable.
In general, 1st overall is the best and 2nd overall is the second best. 1st overall guarantees CMC, then there are a lot of good ways to go from there. I personally like grabbing Waller and then the best RB/WR available at the 3.01, usually Joe Mixon or Michael Thomas.
Draft one starting running back and wide receiver in the first two rounds, and then repeat the pattern in the third and fourth rounds. You should come out of the first two rounds with two RBs and two WRs, and then take a third WR in the fifth round if three starters are required.
Salary Cap drafts are available to Standard and League Manager (LM) Leagues. Leagues that use the Salary Cap mode to draft are set up with a preset budget ($200) to sign enough players to fill their roster. Team managers continue to submit offers until there is a single remaining high salary offer.
Live Salary Cap Draft - Managers take turns nominating a player and all managers can place an offer for that player using a budget. The top offer is then able to sign the player to their roster. Available in all league types.