Rarely, a patent foramen ovale can cause a significant amount of blood to go around the lungs. This lowers blood oxygen levels, a condition called hypoxemia. Stroke. Sometimes small blood clots in veins may travel to the heart.
PFO often doesn't cause any symptoms and may not require treatment. But it can sometimes indicate stroke or mini-stroke. If you have a history of stroke or blood clots, your provider may suggest treatment.
Patent foramen ovale (PFO) occurs when a remnant of normal fetal anatomy abnormally persists into adulthood. It represents a benign finding in the newborn periods. If PFO persists into adulthood, it usually leads to right-to-left shunting of deoxygenated blood, which can be symptomatic or asymptomatic.
Stroke is the major potential complication of PFO. People who have a PFO are slightly more likely to have a stroke than people who do not. A PFO is more likely to be the cause of stroke in a younger adult because younger people don't have as many risk factors for stroke from other causes.
The foramen ovale plays a vital role in sustaining life in-utero; however, a patent foramen ovale (PFO) after birth has been associated with pathologic sequelae in the systemic circulation including stroke/transient ischemic attack (TIA), migraine, high altitude pulmonary edema, decompression illness, platypnea- ...
High-risk PFO is characterized by (D) PFO size of >3 mm (arrow) or (E) the presence of atrial septal aneurysm with (F) hypermobility of the septum during the Valsalva maneuver resulting in a large PFO size (arrow).
PFO itself often does not cause any symptoms. PFO can sometimes result in complications. The most serious of these is stroke. Most people will not need treatment for a PFO.
Patent foramen ovale is prevalent in 20–34% of the population1 and are generally benign and asymptomatic. Occasionally, they can give rise to systemic emboli, which can cause both ocular and cerebral ischaemic events, such as cryptogenic strokes.
However, a PFO can allow those clots to bypass the lungs and cross to the left side of the heart. From there, they can be pumped to the brain, causing a stroke. People who have a PFO and have had an embolic stroke of unknown cause may be at an increased risk for having a second stroke.
Evidence suggests PFO has a genetic predisposition. Genetic variants associated with PFO would serve as biomarkers used for screening high risk individuals. Specific genes that contribute to FO closure are largely unknown. This is attributed to our incomplete understanding of the physiological process of FO closure.