Stroke is the major possible complication of a PFO. People who have a PFO are slightly more likely to have a stroke than people who don't. A PFO is more likely to be involved in a stroke of a younger adult. That's because younger people don't have as many risk factors for stroke from other causes.
Medicines alone. Patients take medicines to prevent blood clots. Surgical procedure to close the PFO, plus medicines. A doctor inserts a medical device through a vein to the PFO. The device closes the PFO and remains in the heart permanently. Patients also take medicines to prevent blood clots.
The opening is supposed to close soon after birth, but sometimes it does not. In about 1 out of 4 people, the opening never closes. If it does not close, it is called a PFO. The cause of a PFO is unknown.
Rarely, a patent foramen ovale can cause a significant amount of blood to go around the lungs. This lowers blood oxygen levels, a condition called hypoxemia. Stroke. Sometimes small blood clots in veins may travel to the heart.
Most PFOs don't need to be closed. Most PFOs cause no symptoms or complications. Larger PFOs may cause stroke. People with symptomatic or large PFOs may benefit from a procedure to close the hole.
However, a PFO can allow those clots to bypass the lungs and cross to the left side of the heart. From there, they can be pumped to the brain, causing a stroke. People who have a PFO and have had an embolic stroke of unknown cause may be at an increased risk for having a second stroke.
Effective PFO closure was seen in 86% of patients who received the device. Recurrent stroke occurred in 2.9% who underwent closure and in 3.1% of those on medical therapy (risk difference RD −0.13%, 95% confidence interval CI −2.2% to 2.0%).
A review of the existing literature showed that Le Moigne and colleagues found the rate of stroke in patients with PE and PFO was 21.4% 12, while Di Tullio and colleagues found that the rate of stroke in patients with PFO was 6.2% 10.
These findings indicate that 60,000 to 80,000 cryptogenic ischemic strokes per year in the US occur in patients with a PFO.