All prescription medicines are allowed on airplanes, whether in a carry-on or checked bag. All passenger items must undergo security screening.It is recommended that medication be clearly labeled to facilitate the screening process. 1. Can you take medicine on a plane? You can travel with prescription drugs or medication in both carryon and checked baggage. Carry a written prescription and a letter from your doctor explaining the medication and medical condition. It is illegal to send prescription drugs through domestic and international mail within and from the United States. Does the FAA have a list of prescription and over-the-counter drugs that pilots can and cannot take while flying? View the full FAQ here. The FAA does not maintain a list of acceptable medications.