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Mitigating factors are extenuating circumstances that might lead to a reduced sentence. (a) Mitigating Factors.The results suggest that jurors have a discernible moral compass. Aggravating factors are presented in an effort to convince a judge or jury to hand down a harsher punishment. "Completed request", for purposes of IC 35-47-8. To reach a sentencing decision, judges typically take into account the total number of mitigating circumstances versus any aggravating ones. These factors can affect the outcome of a defendant's case in a good or bad way. ROS aggravates NLRP3 inflammasome activation, which activates caspase-1, IL-1β, and IL-18 and induces pyroptosis; these factors propagate inflammation. ROS aggravates NLRP3 inflammasome activation, which activates caspase-1, IL-1β, and IL-18 and induces pyroptosis; these factors propagate inflammation.