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True alternatives to the randomized format include the self-controlled study and the historical control design. Both possess significant ethical advantages over the simple randomized study. Unfortunately, both are at some methodological disadvantage when the same comparison is made.
Additional alternatives to the RCT have also been presented, including interrupted time-series, stepped-wedge, regression discontinuity, and N-of-1 trial designs that may limit interval validity but are more responsive and relevant for evaluating mHealth interventions [
How To Randomize? Simple Randomization. Randomization based on a single sequence of random assignments is known as simple randomization. ... Block Randomization. ... Stratified Randomization. ... Covariate Adaptive Randomization.
To further reduce the chance of bias, trials that include randomization are sometimes ?blinded.? Single-blinded trials are those in which you do not know which group you are in and which intervention you are receiving until the trial is over.
When conducting a randomized controlled trial (RCT) is unfeasible, the goal is to replicate the randomization process by creating a control group that is essentially equivalent to the treatment group on known pre-intervention characteristics and assume that the remaining unknown characteristics will not bias the ...