A major new study released by The Lancet Neurology shows that, in 2021, more than 3 billion people worldwide were living with a neurological condition. The World Health Organization (WHO) contributed to the analysis of the Global Burden of Disease, Injuries, and Risk Factor Study (GBD) 2021 data.
Neurological disorders are the leading cause of physical and cognitive disability across the globe, currently affecting approximately 15% of the worldwide population 1. Absolute patient numbers have considerably climbed over the past 30 years.
Conditions Alzheimer's disease and other memory disorders. Ataxia. Huntington's disease. Parkinson's disease. Motor neuron disease. Multiple system atrophy. Progressive supranuclear palsy.
Currently available therapies for neurodegenerative diseases. While there is no definitive cure for most neurodegenerative diseases, there are various therapies and interventions available to help manage symptoms, slow disease progression, and improve the quality of life for individuals affected by these conditions.
Importantly, evidence suggests that disruptions of circadian functions could be early manifestations of neurodegeneration, and might even be a risk factor for the development of neurodegenerative diseases in healthy adults older than 60 years (7–9).
Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington's disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB).
Common neurologic disorders that are accompanied by sleep problems and disorders include: Alzheimer's disease and other dementias. Epilepsy. Neuromuscular disorders.
Neurodegenerative disorders associated with abnormal tau accumulation, including AD, progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), are commonly associated with sleep disorders, mainly due to underlying damage to sleep-controlling brain regions but also to underlying psychiatric, medical, ...
There are several different types of sleep-wake disorders, of which insomnia is the most common. Other sleep-wake disorders include obstructive sleep apnea, parasomnias, narcolepsy, and restless leg syndrome.
Neurodegenerative disorders include: Alzheimer's disease and other memory disorders. Ataxia. Huntington's disease. Parkinson's disease. Motor neuron disease. Multiple system atrophy. Progressive supranuclear palsy.