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Antigens allow your body to create a defense against future invaders. Antibodies circulate in your body once created to identify, attack, and destroy the same type of antigens if they enter the body again.
Examples are alphafetoprotein (AFP) and carcinoembryonic antigen (CEA). These proteins are normally produced in the early stages of embryonic development and disappear by the time the immune system is fully developed. Thus self-tolerance does not develop against these antigens.
Antigen recognition by B cells involves direct binding of immunoglobulin to the intact antigen and, as discussed in Section 3-8, antibodies typically bind to the surface of protein antigens, contacting amino acids that are discontinuous in the primary structure but are brought together in the folded protein.
An antigen is any substance that causes your immune system to produce antibodies against it. This means your immune system does not recognize the substance, and is trying to fight it off. An antigen may be a substance from the environment, such as chemicals, bacteria, viruses, or pollen.
Tumors may express antigens normally expressed during the developing cells of the parent tissue, examples being the wide variety of lymphocyte antigens expressed on lymphomas, prostate-specific antigen in prostate carcinoma, and thyroglobulin in thyroid carcinomas.