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In serum, phosphate exists in two forms, dihydrogen phosphate (H2PO4) and its salt, mono-hydrogen phosphate (HPO4). The relationship between these two can be determined by the Henderson-Hasselbalch equation. At the physiologic pH of 7.40, the pK of H2PO4 is 6.8 and the ratio of HPO4 to H2PO4 is .
The phosphate comes from sediment that was deposited in layers on the sea floor. The phosphate rich sediments are believed to have formed from precipitation of phosphate from seawater along with the skeletons and waste products of creatures living in the seas.
There are two forms of phosphate present in the serum, dihydrogen phosphate( H2PO4) and mono hydrogen phosphate (HPO4); the balance between these two forms depends on the acid-base status of the body.[1][2]
There are two types of phosphate deposit: igneous and sedimentary (Fig. 1). Igneous ores are typically carbonatite, which is an igneous rock with over 50 vol % carbonate minerals (Woolley and Kempe, 1989; Le Maitre, 2002).
Phosphates exist in three forms: orthophosphate, metaphosphate (or polyphosphate) and organically-bound phosphate; each compound contains phosphorous in a different chemical arrangement.