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A simple method of gene annotation relies on homology based search tools, like BLAST, to search for homologous genes in specific databases, the resulting information is then used to annotate genes and genomes.

Structural annotations are physical regions of a genome that encode a genomic feature. Examples of such annotations are genes, mRNA, transcript, repeat sequences, etc.

As a process of identification of gene location and coding regions, gene annotation helps us have an insight of what these genes do in the body by establishing structural aspects and relating them to functions of different proteins.

Functional annotation consists of three main steps:Identifying portions of the genome that do not code for proteins.Identifying elements on the genome, a process called gene prediction.Attaching biological information to these elements.

Gene annotation involves the process of taking the raw DNA sequence produced by the genome-sequencing projects and adding layers of analysis and interpretation necessary to extracting biologically significant information and placing such derived details into context.

Genome annotation consists of three main steps:.identifying portions of the genome that do not code for proteins.identifying elements on the genome, a process called gene prediction.attaching biological information to these elements.

Functional annotation consists of three main steps:Identifying portions of the genome that do not code for proteins.Identifying elements on the genome, a process called gene prediction.Attaching biological information to these elements.

DNA annotation or genome annotation is the process of identifying the locations of genes and all of the coding regions in a genome and determining what those genes do. An annotation (irrespective of the context) is a note added by way of explanation or commentary.

The Annotation Release name is the combination of the organism name and Annotation Release number (e.g. NCBI Pongo abelii Annotation Release 103) and is used throughout NCBI as a way to uniquely identify annotation products originating from the same annotation run.

Sequence annotations describe regions or sites of interest in the protein sequence, such as post-translational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. Sequence conflicts between references are also described in this manner.