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An infusion of IV epinephrine provides greater control. If the patient has an adverse event, then the epinephrine can be stopped or down-titrated. Thus, using an epinephrine infusion may actually encourage the use of epinephrine overall – because you don't have to make a commitment to give the drug for ~30 minutes.

Epinephrine injection comes as a prefilled automatic injection device containing a solution (liquid) and in vials to inject subcutaneously (under the skin) or intramuscularly (into the muscle). It is usually injected as needed at the first sign of a serious allergic reaction.

Adverse Effects The more common side effects include tachycardia, hypertension, headache, anxiety, apprehension, palpitations, diaphoresis, nausea, vomiting, weakness, and tremors. Careful monitoring of vital signs is crucial, especially in patients with polypharmacy.

For two decades, epinephrine injections have been recommended to be delivered intramuscularly (IM) into the mid antero-ventral thigh [7].

This medicine is injected under the skin or into the muscle of your outer thigh only. Do not inject this medicine into a vein, into the muscle of your buttocks, or into your fingers, toes, hands, or feet. To do so, may increase the chance of having serious side effects.