What is the mechanism of action of aldosterone synthase inhibitors?

The mechanism of action of baxdrostat as an aldosterone synthase inhibitor demonstrates the inextricable linkage between sodium and blood pressure regulation.

What are the benefits of Baxdrostat?

Clinical Use Additionally, phase 1 trials indicated Baxdrostat's potential to lower orthostatic blood pressure. Given its effectiveness in treating hypertension, it can be used to lower the risk of stroke and myocardial infarction.

Is Baxdrostat an ACE inhibitor?

Baxdrostat is a highly selective aldosterone synthase inhibitor; phase 1 studies showed that the therapy caused a sustained, dose-dependent reduction in plasma aldosterone by more than 70% without reducing cortisol.

Is Baxdrostat a aldosterone synthase inhibitor?

The selective aldosterone synthase inhibitor Baxdrostat significantly lowers blood pressure in patients with resistant hypertension. Resistant hypertension is defined by blood pressure (BP) targets not achieved despite the use of at least 3 anti-hypertensive drugs of different classes, including a diuretic (1).

What is the mechanism of action of Baxdrostat?

Mechanism of action Baxdrostat targets aldosterone synthase, encoded by the CYP11B2 gene. Importantly, the drug has low affinity for the the enzyme responsible for cortisol synthesis, which is also encoded by the CYP11B1 gene.

Get CA CLIN 107 2009-2024

Ion See California Welfare and Institutions Code (W & I ) Code, Section 5328 W & I Code, Section 5157, requires that each person when first detained for psychiatric evaluation be given certain specific information orally, and a record be kept of the advisement by the evaluating facility. Advisement Complete Advisement Incomplete Good Cause For Incomplete Advisement My name is ___________________________________ I am a (Peace Officer, etc.) with (Name of Agency). You are not under criminal arre.

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