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17) Duplication of reported dataset (n 14) No data reported for CYP2D6 variants (n 9) Modelling analysis (n 5) Breast cancer risk study (n 2) Meta-analysis of included studies (n 1) Footnotes: The flow diagram template was adopted from the PRISMA statement. 1 1 References 1. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine 6: e1000097. 2.

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