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National Inventory Of Wild Poliovirus Materials Http ... - HHS Archive
Get National Inventory Of Wild Poliovirus Materials Http ... - HHS Archive
Fecal, or autopsy Animal Environmental (water/sewage) No Virus isolates or reference strains If NO, please complete Section B. If YES, please respond to question 2. 2. Do stored materials include any of the following? Yes No Throat, fecal, or environmental materials collected for any purpose at a time or in a geographical area where polio was endemic (see Appendices I and II) Clinical materials from polio cases Untyped enterovirus-like or undifferentiated poliov.
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CLIFTON FAQ
There are three variations of poliovirus, called wild poliovirus type 1, 2 and 3 (WPV1, WPV2 and WPV3). Wild polio types 2 and 3 have been eradicated (no longer exist), and wild polio type 1 only exists in a few parts of the world. Polio type 1 is most likely to cause paralysis.
Wild poliovirus (WPV) is the most commonly known form of the poliovirus. However, there is another form of polio that can spread within communities: circulating vaccine-derived poliovirus, or cVDPV. While cVDPVs are rare, they have been increasing in recent years due to low immunization rates within communities.
Poliovirus containment is a key objective of the World Health Organization's Global Polio Eradication Initiative. “Poliovirus-essential” facilities must take steps to keep the virus from being reintroduced to the public and causing harm.
Endemic transmission of wild poliovirus is continuing to cause cases in border areas of Afghanistan and Pakistan. Failure to stop polio in these last remaining areas could result in as many as 200 000 new cases every year within 10 years, all over the world.
Polio is an illness caused by a virus that mainly affects nerves in the spinal cord or brain stem. In its most severe form, polio can lead to a person being unable to move certain limbs, also called paralysis. It can also lead to trouble breathing and sometimes death. The disease also is called poliomyelitis.
The poliovirus consists of an RNA genome enclosed in a protein shell called a capsid. There are three serotypes of wild poliovirus type 1, type 2, and type 3 each with a slightly different capsid protein. Immunity to one serotype does not confer immunity to the other two.
Type 2 wild poliovirus was declared eradicated in September 2015. The last detection was in India, 1999. Type 3 wild poliovirus was declared eradicated in October 2019.
There are three poliovirus serotypes (type1, type 2, and type 3); immunity to one serotype does not produce significant immunity to the other serotypes. Poliovirus is rapidly inactivated by heat, formaldehyde, chlorine, and ultraviolet light.
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