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Health, Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK A E Ades J Walker Department of Biochemistry, Great Ormond Street Hospital NHS Trust, Great Ormond Street, London WC1N 3JH, UK R Jones Department of Metabolic Medicine, Great Ormond Street Hospital NHS Trust I Smith Correspondence to: Dr Ades, MRC Health Services Research Collaboration, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK t.ades bristol.ac.uk Accepted 9 January 2001 Abstract Objectives.

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