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IMR/CaRC/HAEM/22/2203/03(1)/REQForm DNA ANALYSIS FOR THALASSEMIA SYNDROMES Molecular Hematology Laboratory Pathology Department Hospital Kuala Lumpur 50586 Kuala Lumpur, Malaysia Molecular Genetics.

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How to fill out the Borang DNA Analysis online

This guide provides you with comprehensive, step-by-step instructions on completing the Borang DNA Analysis form online. It is designed to be user-friendly and supportive, offering clear directions to help you navigate the process efficiently.

Follow the steps to successfully complete your Borang DNA Analysis online

  1. Click ‘Get Form’ button to obtain the form and open it in the editor. This action will allow you to access the necessary fields required for submission.
  2. Begin filling out the patient information section. Input the patient’s name, date of birth, age, and identification number. Ensure all details are accurate to prevent processing delays.
  3. Indicate the patient's ethnicity by selecting from the given options, which include Malay, Chinese, Indian, or others. This information may be relevant for the analysis.
  4. Provide the address where you would like the report to be sent, including the hospital or clinic name. This is crucial for receiving the results.
  5. Select the patient's gender and answer the question regarding pregnancy if applicable. Make sure to provide the correct number of weeks if the patient is pregnant.
  6. Fill in the family history section by including relevant details about any previous DNA testing in the family. This context can aid in the analysis.
  7. Complete the section regarding the clinical diagnosis by selecting the appropriate status and entering pertinent clinical features like age at diagnosis and hemoglobin levels.
  8. Choose the type of test request by marking the relevant option(s) based on the patient's condition. If applicable, provide additional details about the index case.
  9. Attach any required documentation as indicated in the important checklist. Ensure you include copies of necessary lab results.
  10. Once all sections are complete, review the form thoroughly for accuracy. After confirming the information is correct, save your changes and choose to download or print the form for submission.

Begin your DNA analysis documentation process today by filling out the Borang DNA Analysis online.

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For DNA testing the most popular and reliable way to collect samples is the oral buccal swab method. A buccal swab closely resembles a one ended Q-Tip in appearance. Using swabs as a collection method is quick and painless and is the recommended way to collect DNA samples for testing.

Every child inherits four genes that make alpha globin: two from each parent. Someone with alpha thalassemia has a change (or mutation) in the alpha globin gene that causes less alpha globin to be made than typical. The decrease in alpha globin causes an imbalance in the amount of alpha and beta globin.

What is Thalassemia Mutation Testing? Thalassemia Mutation Testing refers to the analysis of HBA1 and HBA2 genes for alpha-thalassemia and HBB gene for beta-thalassemia to understand the presence of the mutation and inheritance patterns that lead to thalassemia and other related genes.

Doctors diagnose thalassemias using blood tests, including a complete blood count (CBC) and special hemoglobin tests. A CBC measures the amount of hemoglobin and the different kinds of blood cells, such as red blood cells, in a sample of blood.

Deletions of HBA1 and/or HBA2 tend to underlie most cases of α-thalassemia. The severity of symptoms depends on how many of these genes are lost. Loss of one or two genes is usually asymptomatic, whereas deletion of all four genes is fatal to the unborn child.

Today, DNA identity testing is widely used in the field of forensics and paternity identification. Other clinical applications are based upon the methods developed for forensic testing.

DNA testing is the only way to determine silent alpha thalassemia trait and the related hemoglobin trait called hemoglobin Constant Spring. DNA testing may also be necessary in order to allow for the option of prenatal testing.

The most common form of DNA analysis is called polymerase chain reaction (PCR). The development of PCR testing has greatly advanced the field of forensic DNA testing by increasing the success rate of the analysis of old, degraded, or very small biological evidentiary samples.

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