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ISSN 0975-6299 Vol.1/Issue-3/Jul-Sep.2010 International Journal of Pharma and Bio Sciences SOLUBILITY ENHANCEMENT OF A DRUG BY LIQUISOLID TECHNIQUE SANTHOSH KUMAR.K*1, SURIA PRABHA.K1, SATISH.K1,.

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Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response.

Solubility is based on the highest-dose strength of an immediate release product. A drug is considered highly soluble when the highest dose strength is soluble in 250 mL or less of aqueous media over the pH range of 1 to 7.5.

Based on the concentration of solute dissolves in a solvent, solutes are categorized into highly soluble, sparingly soluble or insoluble.

Drugs that dissolve in water (water-soluble drugs), such as the antihypertensive drug , tend to stay within the blood and the fluid that surrounds cells (interstitial space). Drugs that dissolve in fat (fat-soluble drugs), such as the antianxiety drug , tend to concentrate in fatty tissues.

In the liquisolid compact, the product particles are first dissolved, partially dissolved or suspended in the non-volatile liquid vehicle and subsequently adsorbed on the suitable carrier and coating excipients to make non-adherent, free flow and compressible powder mixture.

For pharmaceutical purposes, solubility testing measures the solubility of solid drug compounds in liquid immersions. Solubility testing must be performed under strict laboratory conditions, and the method used to analyze the solubility must be reproducible and documented.

Liquisolid technique refers to the conversion of liquid medications into apparently dry, non-adherent, free flowing and compressible powder mixtures by blending the liquid medications with suitable excipients, which are generally termed as carriers and coating materials [18], [19].

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232