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Carcinogenesis vol.22 no.4 pp.535 545, 2001 The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis Maryann E.Smela, Sophie S.Currier, Elisabeth A.Bailey and John.

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Aflatoxin B1 is known to cause hepatocellular carcinoma by inducing mutation in the tumor suppressor gene TP53. We present in this review the mechanism by which aflatoxin B1 inhibits the type I signaling pathway thus pre-disposing exposed individuals to cancers and other infections.

Aflatoxin toxicity may result in nausea, vomiting, abdominal pain, convulsions, and other signs of acute liver injury. Long-term exposure also leads to various complications like growth retardation, cirrhosis, and hepatocellular carcinoma.

Aflatoxin B1 is an abundant food contaminant and human genotoxic carcinogen (IARC Group 1). Aflatoxin B1 is one of the main risk factors for the development of hepatocellular carcinoma, one of the most aggressive human cancers.

Aflatoxin B1 is an abundant food contaminant and human genotoxic carcinogen (IARC Group 1). Aflatoxin B1 is one of the main risk factors for the development of hepatocellular carcinoma, one of the most aggressive human cancers.

AFB1 is a genotoxic hepatocarcinogen that presumptively causes cancer by inducing DNA adducts, leading to genetic changes in the target cells, which then cause DNA strand breakage, DNA base damage and oxidative damage that may ultimately lead to cancer.

Which cancers are associated with exposure to aflatoxins? Exposure to aflatoxins is associated with an increased risk of liver cancer.

Aflatoxins are a class of compounds with the molecular mass of C17H12O6. They are mainly caused by contamination by A. flavus and A. parasiticus.

Aflatoxin B1 is metabolized to a reactive epoxide (aflatoxin 8,9-epoxide) primarily by the P450 monooxygenase system. In humans, the epoxidation reaction is catalyzed by CYP1A2 and CYP3A4. Once formed, the epoxide can react further to form DNA adducts (aflatoxin-N7-guanine) and induce mutations and cancer.

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Adoption
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Divorce
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Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232