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Avoid inappropriate exclusions? Index Test 4. Were the index test results interpreted without knowledge of the results of the reference standard? 5. If a threshold was used, was it pre‐ specified? Reference Standard 6. Is the reference standard likely to correctly classify the target condition? 7. Were the reference standard results interpreted without knowledge of the results of the index test? Flow and Timing 8. Was there an appropriate interval between index tests and reference standard?.

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