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Approved: Homme Hellinga, Supervisor David Beratan Terrence Oas Weitao Yang Pei Zhou Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Program in Computational Biology and Bioinformatics in the Graduate School of Duke University 2010 ABSTRACT Analysis and Redesign of Protein-Protein Intera.

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The artificial intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein–protein interactions (PPIs).

Protein and protein interactions (PPIs), which refers to intentional physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.

Protein-protein interactions (PPIs) are the physical contacts between two or more proteins and they represent complex biological functions. Nowadays, PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins.

Protein-protein interactions (PPIs) play a pivotal role in many dynamic biological processes. Since the dysregulation of PPIs often affects the onset and the progression of several diseases, targeting PPIs is a challenging task when attempting to convert drug-like small molecules to therapeutics.

Four major types of attractive interactions determine the shape and stability of the folded protein: ionic bonding, hydrogen bonding, disulfide linkages, and dispersion forces.

Protein–protein interaction experiments. The most widely used two high-throughput methods for obtaining protein–protein interaction data are yeast two-hybrid (top left) and affinity purification mass spectrometry (top right).

Characterizing protein–protein interactions through methods such as co-immunoprecipitation (co-IP), pull-down assays, crosslinking, label transfer, and far–western blot analysis is critical to understand protein function and the biology of the cell.

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Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Content Takedown Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232