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Ed: Mariano Garcia-Blanco, Co-Advisor Mark Dewhirst, Co-Advisor Michael Datto Joseph Lucas Joseph Nevins, Chair Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Molecular Cancer Biology in the Graduate School of Duke University 2010 ABSTRACT Detecting Changes in Alternative mRNA.

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This allows a single gene to produce various protein variants, which increases protein diversity and enables cells to respond to different conditions. Alternative splicing plays a crucial role in tissue-specific gene expression, gene regulation, protein diversity, and is also linked to disease and development.

Alternative splicing is a cellular process in which exons from the same gene are joined in different combinations, leading to different, but related, mRNA transcripts. These mRNAs can be translated to produce different proteins with distinct structures and functions — all from a single gene.

Alternative splicing can generate mRNAs that differ in untranslated regions (UTR) or the coding sequence, with mechanisms including exon skipping (removal of specific exons, referred to as cassette exons, that can be either included or excluded from the mature transcript depending on alternative splicing decisions), ...

During splicing, coding-regions of mRNA (exons) are kept and non-coding regions of mRNA (introns) are cut out and removed. mRNA Splicing is an important step in the transcription process, as without removing the introns the correct protein cannot be formed.

Alternative splicing allows for mutations to accumulate that won't affect the expression of a gene.

More broadly, alternative splicing enables repurposing proteins from one context to another and thereby contributes to both the evolution of new traits as well as the creation of disease-specific interactomes that drive pathological phenotypes.

Alternative splicing is a mechanism for controlled gene expression that involves the production of multiple mRNA transcripts from a single gene. This mechanism is important for the abundance and diversity of protein isoforms,17,18 and is particularly critical during development for tissue specification.

Alternative splicing is a key cellular process whereby particular combinations of exons in a nascently transcribed pre-mRNA are either included or excluded to generate different mature mRNA splice isoform transcripts, resulting in multiple protein isoforms encoded by a single gene.

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Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Privacy Notice
Legal Hub
Content Takedown Policy
Bug Bounty Program
About Us
Help Portal
Legal Resources
Blog
Affiliates
Contact Us
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate WorkFlow
DocHub
Instapage
Social Media
Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232