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Division of Laboratory Sciences National Center for Environmental Health contact: James L. Pirkle, M.D., Ph.D. Director, Division of Laboratory Sciences Important Information for Users CDC periodically refines these laboratory methods. It is the responsibility of the user to contact the person listed on the title page of each write-up before using the analytical method to find out whether any changes have been made and what revisions, if any, have been incorporated. Soluble Transferrin Rece.
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Hitachi FAQ
The transferrin blood test is ordered if the doctor suspects abnormalities of iron levels in your body. The tests help diagnose chronic iron overload or deficiency. It is a simple blood routine wherein the technician draws the sample from a vein in your arm and sends it to the lab for further analysis.
The method principle for measurement of soluble transferrin receptor (sTfR) is immuno- turbidimetry using Roche kits on the Hitachi 912 clinical analyzer. Latex bound anti-sTfR antibodies react with the antigen in the sample to form an antigen/antibody complex.
Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. The erythroblasts rather than reticulocytes are the main source of serum sTfR.
sTfR represents the state of TfR as a cleaved portion of it and TfR increases when intracellular iron concentration is low. Therefore, sTfR is a useful clinical parameter for assessing functional iron deficiency and erythropoiesis.
Soluble transferrin receptor as a diagnostic laboratory test for detection of iron deficiency anemia in acute illness of hospitalized patients.
143305: Soluble Transferrin Receptor | Labcorp.
Transferrin receptor testing is used to measure the level soluble transferrin receptors, thereby aiding in the evaluation of iron deficiency and in the diagnosis of iron-deficiency anemia. Transferrin is an iron-binding glycoprotein found in the plasma. Its main function is to control the level of free iron.
Increased serum soluble transferrin receptor (sTfR) is a sensitive marker of iron deficiency, reflecting increased expression of this receptor on RBC precursors as a response to depleted tissue iron.
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