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Get Journal Of Antimicrobial Chemotherapy Advance Access Published September 10, 2009 - Jac

S of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer Marie Doyle1, Eva-Anne Feuerbaum1, Keith R. Fox2, Jason Hinds3, David E. Thurston1 and Peter W. Taylor1* 1 Received 29 April 2009; returned 22 June 2009; revised 6 August 2009; accepted 10 August 2009 Objectives: ELB-21 is a pyrrolo 2,1-c 1,4 benzodiazepine dimer with potent antistaphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory prot.

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