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- Journal Of Antimicrobial Chemotherapy Advance Access Published September 10, 2009 - Jac
Get Journal Of Antimicrobial Chemotherapy Advance Access Published September 10, 2009 - Jac
S of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer Marie Doyle1, Eva-Anne Feuerbaum1, Keith R. Fox2, Jason Hinds3, David E. Thurston1 and Peter W. Taylor1* 1 Received 29 April 2009; returned 22 June 2009; revised 6 August 2009; accepted 10 August 2009 Objectives: ELB-21 is a pyrrolo 2,1-c 1,4 benzodiazepine dimer with potent antistaphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory prot.
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Subinhibitory FAQ
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Antimicrobial chemotherapy is a broad term that includes all medications used to target bacteria, viruses, parasites, funguses, and other microorganisms that can cause infections in your body. Antimicrobial chemotherapy can include everything from injected antiviral medications to at-home oral antibiotics.
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Inhibitors of the biosynthesis of the bacterial cell wall 2. Inhibitors of the bacterial protein synthesis 3. Inhibitors of the nucleic acid metabolism 4. Membrane-active antibiotics.
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The 2023-2024 Journal's Impact IF of Journal of Antimicrobial Chemotherapy is 5.758, which is just updated in 2024.
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Inhibition of Cell Wall Synthesis (most common mechanism) Inhibition of Protein Synthesis (Translation) (second largest class) Alteration of Cell Membranes. Inhibition of Nucleic Acid Synthesis.
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Journal of Antimicrobial Chemotherapy Publication detailsImpact factor5.2 (2022)Standard abbreviations ISO 4 (alt) · Bluebook (alt1 · alt2) NLM (alt) · MathSciNet (alt )ISO 4J. Antimicrob. Chemother.Indexing CODEN (alt · alt2) · JSTOR (alt) · LCCN (alt) MIAR · NLM (alt) · Scopus13 more rows
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The mechanisms of resistance can be broken down into the following: Enzyme inactivation and modification. Modification of the antibiotics target site. Overproduction of the target. Replacement of the target site. Efflux and reduced permeability.
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Various antimicrobial agents act by interfering with (1) cell wall synthesis, (2) plasma membrane integrity, (3) nucleic acid synthesis, (4) ribosomal function, and (5) folate synthesis.
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There are six major modes of action: (1) interference with cell wall synthesis, (2) inhibition of protein synthesis, (3) interference with nucleic acid synthesis, (4) inhibition of a metabolic pathway, (5) inhibition of membrane function, (6) inhibition of ATP Synthase (Fig.
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