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Get Evidence For P62 Aggregate Formation: Role In ... - Auburn University - Auburn

And Molecular Biosciences, Auburn University, AL 36849, USA Received 30 May 2005; revised 13 July 2005; accepted 1 August 2005 Available online 18 August 2005 Edited by Jesus Avila Abstract The polyubiquitin-binding protein p62 has been shown to localize in aggregates common to several types of diseases. Here, we report that p62 forms independent brillar aggregates in vitro in a time- and concentration-dependent manner. FTIR spectra and ThT uorescence assay of p62 reveals increased bshee.

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