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Different Forms Of Simian Virus 40 Large Tumor Antigen - NCBI
Get Different Forms Of Simian Virus 40 Large Tumor Antigen - NCBI
LLER,2 BETH BARNET,2 PETROS HANTZOPOULOS,2 MOSHE OREN,1 AND CAROL PRIVES2* Virology Department, Weizmann Institute of Science, Rehovot, Israel,1 and Department of Biological Sciences, Columbia University, New York, New York 100272 Received 19 October 1981/Accepted 14 January 1982 In various permissive monkey cell lines infected with simian virus 40 there are two major forms of large T antigen which differ in their rate of sedimentation through sucrose gradients. The lighter (5 to 7S) form sedi.
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The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Emergent Human Pathogen Simian Virus 40 and Its Role in Cancer - PMC nih.gov https://.ncbi.nlm.nih.gov › articles › PMC452549 nih.gov https://.ncbi.nlm.nih.gov › articles › PMC452549
The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Emergent Human Pathogen Simian Virus 40 and Its Role in ... National Institutes of Health (.gov) https://.ncbi.nlm.nih.gov › articles › PMC452549 National Institutes of Health (.gov) https://.ncbi.nlm.nih.gov › articles › PMC452549
The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication, and alteration of the cell cycle. T Antigens of Simian Virus 40: Molecular Chaperones for Viral ... nih.gov https://.ncbi.nlm.nih.gov › articles › PMC120785 nih.gov https://.ncbi.nlm.nih.gov › articles › PMC120785
SV40 T-ag can be considered a dual oncogene protein; it is a composite transforming protein that provides distinct functions at different subcellular locations. In addition to its roles in virus replication, T-ag exerts numerous effects on host cells. SV40 large T-antigen: dual oncogene - PubMed nih.gov https://pubmed.ncbi.nlm.nih.gov › ... nih.gov https://pubmed.ncbi.nlm.nih.gov › ...
The SV40Tag oncoprotein is an inactivating ligand of p53 and retinoblastoma (Rb) protein, serving to eliminate the tumor suppressing function of p53 and Rb and to permit tumor formation. Virus Large T Antigen - an overview | ScienceDirect Topics ScienceDirect https://.sciencedirect.com › topics › virus-large-t-ant... ScienceDirect https://.sciencedirect.com › topics › virus-large-t-ant...
SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. SV40 large T antigen - Wikipedia wikipedia.org https://en.wikipedia.org › wiki › SV40_large_T_antigen wikipedia.org https://en.wikipedia.org › wiki › SV40_large_T_antigen
Simian virus 40 (SV40) is a small, DNA-containing tumour virus. One of its gene products, the large tumour antigen (T-ag), is essential for both viral replication and cell transformation. SV40 large T-antigen: dual oncogene - PubMed National Institutes of Health (.gov) https://pubmed.ncbi.nlm.nih.gov › ... National Institutes of Health (.gov) https://pubmed.ncbi.nlm.nih.gov › ...
The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication, and alteration of the cell cycle. T Antigens of Simian Virus 40: Molecular Chaperones for Viral ... National Institutes of Health (.gov) https://.ncbi.nlm.nih.gov › articles › PMC120785 National Institutes of Health (.gov) https://.ncbi.nlm.nih.gov › articles › PMC120785
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Different forms of simian virus 40 large tumor...
by D Gidoni · 1982 · Cited by 84 — In various permissive monkey cell lines infected...
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