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As the asylum's buildings were vacated, four were converted into prisons. One prison remains on the property today. In a separate facility, the Cook Building, the hospital houses 179 forensic patients (who have been found by courts to be not guilty by reason of insanity or incompetent to stand trial).

On Feb. 21, 1905, the Indiana legislature passed a bill to construct a mental institution in southeastern Indiana. A commission named for the purpose chose Madison as the site of the institution. It was built mostly on land purchased from Henry and Ford Hitz at $100 per acre, atop the hills overlooking the Ohio River.

Three forces drove the movement of people with severe mental illness from hospitals into the community: the belief that mental hospitals were cruel and inhumane; the hope that new antipsychotic medications offered a cure; and the desire to save money [8].

With patients all but gone, the dozens of deteriorating buildings are all that remains of Central State Hospital. The site is now a patchwork of state and private ownership, with much of the area managed by a local redevelopment authority.

The Central State Hospital Campus Driving Tour is a self-guided driving tour that highlights the historic buildings of the campus and mentions important people from Central State Hospital's past as well as the significance of certain periods in the Hospital's history.

It was built mostly on land purchased from Henry and Ford Hitz at $100 per acre, atop the hills overlooking the Ohio River. The first patients were accepted at the new Southeastern Indiana Hospital for the Insane on Aug. 23, 1910.

Central State Hospital, formerly referred to as the Central Indiana Hospital for the Insane, was a psychiatric treatment hospital in Indianapolis, Indiana.