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R for Molecular Medicine & Genetics, 2Department of Immunology and Microbiology, 3Karmanos Cancer Institute, The Wayne State University School of Medicine, Detroit, MI 48201, USA. Received December 12, 2009; accepted January 4, 2010; available online January 8, 2010 Abstract: There has been much effort to define the molecular basis by which pathophysiological stimuli initiate and/ or propagate the inflammatory response. Recent research endeavors on stress response from a cellular organelle cal.

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