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Hear this out loud PauseIn the “replication-independent” active demethylation, TET dioxygenases sequentially oxidize 5mC to 5-hydroxymethylcytosine (5hmC), and further to 5-formylcytosine (5fC), and finally to 5-carboxylcytosine (5caC). 5fC and 5caC are then removed by base excision repair (BER), namely by DNA glycosylases (Figure 2).
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