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SAR1 10/21Age retirement Benefit application1. Explanatory notes 2. Form 3. Departmental report form Important information about this form What this form is forThis benefit application form and Explanatory.

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The small GTPase protein Sar1 is required for the formation of the COPII vesicle from the ER [7]. Upon exchanging GDP for GTP, Sar1 undergoes a conformational change that exposes an N-terminal amphipathic α-helix allowing it to insert into the outer membrane leaflet [4].

The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane.

Sar1 is an Arf family small GTPase initially identified as a multicopy suppressor of a temperature-sensitive Sec12 mutant in yeast (Nakano and Muramatsu, 1989).

Activated Sar1 is recruited to ER membranes and forms a pre-budding complex with cargoes and the inner-coat complex. The outer-coat complex then stimulates Sar1 inactivation and completes vesicle formation.

Sar1 binds to the ER membrane through its N-terminal amphipathic helix, which is exposed only upon GTP binding and plays a primary role in membrane remodeling during vesicle formation and fission (Antonny et al., 1997; Aridor et al., 2001; Huang et al., 2001; Bielli et al., 2005; Lee et al., 2005; Hariri et al., 2014; ...

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© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232
Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232
AU SAR1
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