Get Halt Pkd Efficacy Of Aggressive Renin-angiotensin-aldosterone Axis Blockade In Preventing/slowing 2012-2025

Blockade of RAAS has been shown to be beneficial in patients with hypertension, acute myocardial infarction (AMI), chronic systolic heart failure, stroke and diabetic nephropathy (DN). ACE inhibitor (ACEI) and angiotensin receptor blocker (ARB) are two major RAAS inhibitors commonly used in clinical practice.

ADPKD is progressive, which means it gets worse over time. In fact, it often results in chronic kidney disease, a gradual loss of kidney function.

The HALT Progression of Polycystic Kidney Disease (HALT PKD) studies were two simultaneous multicenter clinical trials designed to test the efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and the decline in renal function in ADPKD.

There are 2 procedures that are most commonly used to treat simple kidney cysts: Aspiration and sclerotherapy: The doctor inserts a long needle under the skin to puncture the cyst and drain the fluid. A strong solution is then injected into the cyst to shrink it. This procedure can be repeated, if necessary.

Controlling high blood pressure can delay the progression of the disease and slow further kidney damage. Combining a low-sodium, low-fat diet that's moderate in protein and calorie content with not smoking, increasing exercise and reducing stress may help control high blood pressure.

We found that antihypertensive regimens containing ACE inhibitors were more effective in slowing the progression of kidney disease compared to regimens without ACE inhibitors.

There's currently no cure for autosomal dominant polycystic kidney disease (ADPKD), and it's not possible to stop cysts forming in the kidneys. But there are some potentially useful medications, such as , that can sometimes be used to reduce the growth rate of cysts.