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Targeting FGFR alterations in cancer with BGJ398, a selective FGFR inhibitor Randi Isaacs MD Novartis Institutes for BioMedical Research Translational Clinical Oncology 2 Cholangiocarcinoma Foundation.

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Targeting FGFR with BGJ398 in Breast Cancer:...
by A Sahores · 2018 · Cited by 17 — Genomic alterations in FGFR have been identified...
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The majority of SNVs in FGFR have been reported to occur in FGFR2 and are found at high frequencies in endometrial cancer (12%), non-small cell lung cancer (4%) and gastric cancer (4%).

FGFR mutations are frequent in human cancers (16, 22), with the highest prevalence in NSCLC (FGFR1 range 0–18%) (17, 20, 23, 62), endometrial carcinoma (FGFR2, range 0–9%) (35, 63), bladder carcinoma (FGFR3, range 8.5–26%) (53, 64), and rhabdomyosarcoma (FGFR4 7.5%) (65) (Table 1 and Supplemental Table S2).

The malfunction of FGF/FGF receptor (FGFR) signaling axis is observed in a variety of human diseases, such as congenital craniosynostosis and dwarfism syndromes, as well as chronic kidney disease (CKD), obesity, resistance, and various tumors (Fig. 1).

Fibroblast growth factor receptor gene alterations are common molecular findings in UC. Activating somatic mutations of FGFR3 have been detected in 50–70% of nonmuscle-invasive carcinomas and in 20% of mUC [8,9]. FGFR alterations have been identified as an early event in UC development.

FGFR3 is altered in 2.44% of all cancers with bladder urothelial carcinoma, colon adenocarcinoma, lung adenocarcinoma, infiltrating renal pelvis and ureter urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

Genetic aberrations of FGFR1 are more frequently observed in human cancers (2.86%), followed by alterations in FGFR3 (2.21%), FGFR2 (1.77%), and FGFR4 (1.54%).

Signaling pathways activated by FGFRs inhibit apoptosis, reducing the cytotoxic effect of some anti-cancer drugs. FGFRs-dependent signaling may also initiate angiogenesis and EMT, which facilitates metastasis and also correlates with drug resistance.

Abstract. Fibroblast growth factor receptors (FGFRs) play key roles in promoting the proliferation, differentiation, and migration of cancer cell. Inactivation of FGFRs by tyrosine kinase inhibitors (TKI) has achieved great success in tumor-targeted therapy.

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Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Privacy Notice
Legal Hub
Content Takedown Policy
Bug Bounty Program
About Us
Help Portal
Legal Resources
Blog
Affiliates
Contact Us
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate WorkFlow
DocHub
Instapage
Social Media
Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232