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4760The 9Item Sickle Cell Disease Severity Measure (SCDSM): A Novel Measure of Daily SCD Symptom Severity Developed to Assess Benefit of GBT440, an Experimental HbS Polymerization Inhibitor Laurie.

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How to fill out the SCDSM online

The SCDSM, or Sickle Cell Disease Severity Measure, is a critical tool for assessing daily symptoms in individuals with sickle cell disease. This guide provides you with step-by-step instructions for filling out the SCDSM online, ensuring an accurate representation of your symptom severity.

Follow the steps to successfully complete the SCDSM online.

  1. Press the ‘Get Form’ button to retrieve the SCDSM and open it in the online editor.
  2. Begin by filling out your personal information as requested, including your age, gender, and country of residence. This information is vital for demographic analysis.
  3. Proceed to the symptom section where you will assess your daily symptoms. Respond to each item by selecting the appropriate response that corresponds to how you experienced each symptom over the past day.
  4. Make sure to answer each of the 9 items, which include questions about body aches, pain levels, energy levels, and any difficulty with breathing or concentration. Each question will have a range of response options to quantify the severity and frequency of symptoms.
  5. After answering all items, review your responses to ensure all necessary information was provided and accurately reflects your experiences.
  6. Finally, you have the option to save changes, download, print, or share the completed form as needed.

Complete your SCDSM online today to contribute to improved understanding and management of sickle cell disease.

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The β-globin genotype—that is, the genotype of SCD—is the main determinant of disease severity, especially when considered at the level of the population rather than the individual (Table 1). Overall, HbSS and HbSβ0 are the most severe forms of SCD, while HbSC and HbSβ+ are generally milder diseases (Table 2).

HbSS. People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin “S.” Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped. This is commonly called sickle cell anemia and is usually the most severe form of the disease.

These parameters were scored ing to the frequency of occurrence and severity with scores ranging from 1 to 5. The total score was then calculated for each child (range from 0 to 34), and the disease was classified as mild when the total score was <8, moderate was 8–17, and severe when the total score was >17.

The sickle cells die early, which causes a constant shortage of red blood cells. Also, when they travel through small blood vessels, they get stuck and clog the blood flow. This can cause pain and other serious complications (health problems) such as infection, acute chest syndrome and stroke.

Assessment of disease severity score The total severity score was calculated as Mild SCA [≤3], Moderate SCA [>3 but ≤7], and Severe SCA [>7].

The HbSS and HbSβ0-thalassemia genotypes are often associated with the most severe clinical manifestations, while HbSC and HbSβ+-thalassemia are generally considered less severe. There are multiple compound heterozygous sickling genotypes that so vary in significance and clinical severity.

A normal hemoglobin level is around 12 to 15 g/dL. People with SCD have hemoglobin levels of 6 to 11 g/dL. People with SCD usually have higher levels of white blood cells, especially neutrophils.

People with sickle cell disease (SCD) generally adapt well to air travel, but it can create difficulties for some. For this reason, it is important to plan ahead and know about potential problems so that you can take preventative measures or deal with them should they occur.

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© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232
Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Privacy Notice
Legal Hub
Content Takedown Policy
Bug Bounty Program
About Us
Blog
Affiliates
Contact Us
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate WorkFlow
DocHub
Instapage
Social Media
Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232