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A Journey in Global PUPSIT Implementation with Benchmarking PDA Midwest Event Oct 5th, 2017 Jeff Gaerke P.E.Purpose Share learning on ongoing global implementation of PUPSIT for parenteral operations.

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How is PUPSIT performed? PUPSIT is typically performed by subjecting the sterilized filter to a challenging gas or liquid flow, and then measuring the pressure or flow rate across the filter. If the filter is intact, it should retain the integrity and prevent any particles or microorganisms from passing through.

PUPSIT is a test that is used to ensure the integrity of a sterilizing filter and its associated components, such as the filter housing, support structure, and connections, after the filter has been installed and sterilized but before it is used to filter product.

SFQRM: The use of scientific data to assess and control risks associated with sterilizing filtration.

The Complete Guide to Pre-Use, Post-Sterilization Integrity Testing (PUPSIT)

In the bubble point test, pore size rating is determined by measuring the lowest air pressure needed to overcome the surface tension between the wetting liquid and the membrane pores in a fully wetted membrane.

To perform this test, after the filters are installed and flushed, a specified pressure is applied to the filters, and the air feed valve is closed. After a defined time interval, the pressure is noted, and the pressure decay is calculated (initial pressure minus final pressure).

The use of PUPSIT is necessary because there are concerns that a sterilizing filter may develop flaws that could allow microbiological contamination to pass through during filtration.

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© Copyright 1997-2025
airSlate Legal Forms, Inc.
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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232