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  • Cebp Poises B Cells For Rapid Reprogramming Into Induced Bb - Tesisenred

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C/EBP poises B cells for rapid reprogramming into induced pluripotent stem cells Bruno Di Stefano Doctoral Thesis UPF2014 DIRECTOR Thomas Graf Gene Regulation, Stem Cells and Cancer Department Centre.

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B cells have been shown to be refractory to reprogramming and B-cell-derived induced pluripotent stem cells (iPSC) have only been generated from murine B cells engineered to carry -inducible Oct4, Sox2, Klf4 and Myc (OSKM) cassette in every tissue and from EBV/SV40LT-immortalized lymphoblastoid cell lines.

The original set of reprogramming factors (also dubbed Yamanaka factors) are the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and cMyc.

Reprogramming of cells refers to the regression of a specialized cell to a simpler state, resulting in cells with stem-like properties, or the direct transformation of one specialized cell type into another, which is also known as transdifferentiation.

Currently, cellular reprogramming has commonly been achieved by three methods, somatic cell nuclear transfer (SCNT), cell fusion technology, and the ectopic expression of defined factors (such as Oct4, Sox2, Klf4, and c-Myc, named as OSKM or Yamanaka factors), so as to produce induced pluripotent stem cells (iPSCs).

There are four types of methods that are currently known for reprogramming to (A) totipotency, (B,C) near totipotency, and (D) pluripotency. (For simplicity, we have excluded reprogramming methods using only small molecules, cell-extract treatment, and cell fusion that can also result in ESCs-like cell formation).

Currently, reprogramming technologies are divided into three approaches: (i) somatic cell nuclear transfer (SCNT) technology, (ii) induced PSC (iPSC) technology, and (iii) direct reprogramming (DR) technology [1].

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232