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Than normal enzymatic activity. UMs are at increased risk of failure to active drugs because they clear the drugs too rapidly to benefit from a standard dose. UMs are also at risk of toxic side effects from prodrugs, such as bleeding on , because they convert the drug into an active form more so than expected. Copyright 2012 by PGXL Laboratories.

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CYP2C9 is inhibited by , , and sulphaphenazole among other drugs [9]. Dangerous drug- drug interaction can arise when an inhibitor such as one of these is added to a therapeutic regime that includes drugs with a low therapeutic index, such as S-, tolbutamine, and [40-42].

Omeprazole inhibits CYP2C19 and therefore its own metabolism. This leads to non-linear pharmacokinetics.

CYP2C19 metabolizes numerous commonly used drugs including , clomipramine, , , omeprazole, S-mephenytoin, and biguanides [97–99]. Approximately 2000 SNPs and more than 35 variants have been identified in the CYP2C19 gene.

CYP2C19 strong inhibitors (®) [9] Clomipramine (®) [9] (®) [1] (®) [1] (®) [9] (®) [1]

Tricyclic antidepressants that are known CYP2C19 substrates are: , clomipramine, , and . SSRIs that are known CYP2C19 substrates are , , and .

Table 1-2: Examples of in vitro selective inhibitors for CYP-mediated metabolism EnzymeInhibitorCYP2B6clopidogrel(a), , (a), (a)CYP2C8gemfibrozil glucuronide(a), , (a)CYP2C9sulfaphenazole, tienilic acid(a)CYP2C19N-3-benzyl-nirvanol, loratadine, nootkatone, (a)3 more rows • 24 Aug 2022

Cytochrome P-450 CYP2C19 Inhibitors (strong) DrugTargetTypeLansoprazoleCytochrome P450 2C19enzymeLansoprazoleCytochrome P450 2C9enzymeLansoprazoleCytochrome P450 3A4enzymeLansoprazoleP-glycoprotein 1transporter143 more rows

in particular is primarily metabolized by CYP2C19 [20]. Because the CYP2C19 gene is highly polymorphic, and because is a prodrug requiring bioactivation by this enzyme in vivo, the association between CYP2C19 gene variants and efficacy appears to be clinically actionable.

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Privacy Notice
Legal Hub
Content Takedown Policy
Bug Bounty Program
About Us
Help Portal
Legal Resources
Blog
Affiliates
Contact Us
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate WorkFlow
DocHub
Instapage
Social Media
Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232