Why do drug eluting stents thrombosis?

The exact mechanism of stent thrombosis has not yet been fully explained. Drug-eluting stents prevent restenosis by inhibiting the proliferation of smooth muscle cells that cause neointimal thickening. They accomplish this by slowly releasing potent antiproliferative drugs, the eluting process.

What is the benefit of drug eluting stent?

What are the benefits of a drug-eluting stent? Drug-eluting coronary stents can help prevent plaque buildup, promote good blood flow to your heart, and relieve chest pain. They may also lower your chances of having a heart attack.

Why does stent thrombosis occur?

Late and very late stent thrombosis is usually due to the type of stent (i.e., first generation drug-eluting) and antiplatelet therapy (i.e., premature termination of ADP receptor antagonist within 6 months or complete termination of antiplatelet agents at any time).

What is the mechanism of action of stents?

The drug is mainly to inhibit neointimal growth (due to the proliferation of smooth muscle cells) that would cause restenosis. Much of the neointimal hyperplasia seems to be caused by inflammation. Hence, immunosuppressive and antiproliferative drugs are used.

Why are drug eluting stents better than bare metal?

Drug-eluting stents have a polymer coating over mesh that emits a drug over time to help keep the blockage from coming back. In general, drug-eluting stents are preferred over bare-metal stents for most people. Drug-eluting stents are more likely to keep the blockage from recurring compared to bare metal stents.

Why do drug eluting stents cause thrombosis?

Following this line of reasoning, months after implantation a drug-eluting stent is effectively denuded. The drug coating is depleted and there is no new tissue coating the stent struts. As a result, blood flows directly over a "bare" surface, a perfect set-up for thrombus formation.

Why do drug eluting stents require longer antiplatelet therapy?

To overcome that problem, drugs are imbedded in the stents to slow the growth of the endothelial lining, but of course that also slows down the rate of healing. These second generation drug-eluting stents (DES) therefore require longer periods of dual antiplatelet therapy, up to a year or more.

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EuroIntervention: An Insight Into The Current Use Of Drug Eluting Stents In Acute And Elective

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005 EuroHeart 429.qxd 21/12/07 8:35 Page 429 Focus article An insight into the current use of drug eluting stents in acute and elective percutaneous coronary interventions in Europe A report on the.

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