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  • 1. Cell Cloning By Serial Dilution In 96 Well Plates. Protocol ...

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Cell Cloning by Serial Dilution in 96 Well Plates Protocol Introduction John A. Ryan, Ph.D. Corning Incorporated Life Sciences 900 Chelmsford St Lowell, MA 01851 This technique is widely used for.

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How to use or fill out the 1. Cell Cloning By Serial Dilution In 96 Well Plates. Protocol online

This guide provides comprehensive instructions for completing the Cell Cloning By Serial Dilution In 96 Well Plates Protocol. Designed for both novice and experienced users, this protocol streamlines the process of clonal isolation of cells, ensuring accuracy and efficiency.

Follow the steps to successfully fill out the protocol.

  1. Select the ‘Get Form’ button to access the document and open it in your desired editing platform.
  2. Begin by carefully reading through the introductory section to understand the purpose and applications of this protocol before proceeding to fill out any specific fields.
  3. Gather all required materials listed in the supplies section of the protocol, including specific pipettors and cell culture media.
  4. As you follow the procedural steps, start with filling the reagent dispensing tray and transfer the appropriate volumes to the 96 well plate as outlined in the procedure.
  5. Incorporate any additional notes or observations in the margins of the document to keep track of your specific conditions or outcomes during the cloning process.
  6. Once all procedural steps are completed, ensure all necessary details such as date and cell type are clearly labeled on your protocol.
  7. Finalize your document by reviewing all entries for accuracy, then save your changes. You can also opt to download, print, or share the completed protocol as needed.

Complete your documentation online to ensure structured and efficient cell cloning processes.

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You can calculate your cell concentration using the following formula: Total cells/ml = (Total cells counted x Dilution factor x 10,000 cells/ml)/ Number of squares counted. Total cells/ml = (325 cells x 2 x 10,000 cells/ml)/ 5 = 130 x 104 cells/ml. Total cells in sample = 130 x 104 cells/ml x 5 ml = 650 x 104 cells.

Limiting dilution cloning (LDC) We recommend performing limiting dilution by targeting 0.8 cells/well, which requires you to resuspend the transfected cells (post-counting) at a density of 8 cells/mL in complete growth medium, then transferring 100 μL of this to each well of a 96‑well plate.

Plate 200 µL of cell culture (i.e., 10,000–50,000 cells) into the wells of the sterile 96-well cell culture plate.

You have 3.348 x 10^6 cells. So if you need to seed 10000 cells per well, then for 100 wells you will need 10000 x 100 = 1 x 10^6 cells for a 96-well plate. If you seed cells at 100 ul per well, then you will need a total volume of 100 x 100 = 10000ul = 10 ml for 96-well plate.

You have 3.348 x 10^6 cells. So if you need to seed 10000 cells per well, then for 100 wells you will need 10000 x 100 = 1 x 10^6 cells for a 96-well plate. If you seed cells at 100 ul per well, then you will need a total volume of 100 x 100 = 10000ul = 10 ml for 96-well plate.

For any cell type you can use a minimum of 100ul to a maximum of 200ul culture medium per well in a 96-well plate.

Typically, 20,000 – 75,000 cells are seeded per well in Oris™ and Oris™ Pro 96-well plates, and 2,500 – 10,000 per well in Oris™ Pro 384-well plates.

To perform serial dilution, for example, 1 ml of the starting sample is added to 9 ml of Dilution Blank Tube 1. This is then followed by the same procedure, where 1 ml from Tube 1 is added to 9 ml of Tube 2, 1 ml from Tube 2 is added to 9 ml from Tube 3, and so on until the desired concentration is reached.

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© Copyright 1997-2025
airSlate Legal Forms, Inc.
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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Privacy Notice
Legal Hub
Content Takedown Policy
Bug Bounty Program
About Us
Blog
Affiliates
Contact Us
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate WorkFlow
DocHub
Instapage
Social Media
Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232