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Side effects related to the hormone Oestrogen – breast tenderness, leg cramps, skin irritation, bloating, indigestion, nausea, headaches. Side effects related to the hormone Progesterone - premenstrual syndrome-like symptoms, fluid retention, breast tenderness, backache, depression, mood swings, pelvic pain.

With sequential HRT there should be a bleed after the progestogen part of the medication. It should be like a period and lasts 3–7 days.

Taking your Trisequens Take one tablet a day, preferably at about the same time. Swallow the tablet with a glass of water. Begin by taking the blue tablets for 12 days followed by the white tablets for 10 days and finally the red tablets for 6 days.

Breakthrough bleeding is a common problem in postmenopausal women taking hormone replacement therapy (HRT) and is often the single most important factor deterring women from continuing to use HRT, or from starting it in the first place. The mechanisms which underlie this unscheduled bleeding are poorly understood.

Side effects breast tenderness, pain or enlargement. irregular periods or excessive bleeding during your periods. period pain. abdominal (stomach) pain, indigestion, feeling sick (nausea), vomiting, diarrhoea, bloating, flatulence. skin rash or itching, skin reactions, acne, changes in hair growth, hair loss.

What Trisequens® is used for. Trisequens® is a type of hormone replacement therapy (HRT) that relieves the symptoms of estrogen deficiency associated with the menopause. It is a short term symptomatic treatment, also used where these symptoms arise from medical or surgical procedures affecting the ovaries.

Breakthrough bleeding and spotting may occur during the first months of treatment. If breakthrough bleeding or spotting appears after some time on therapy, or continues after treatment has been discontinued, the reason should be investigated, which may include endometrial biopsy to exclude endometrial malignancy.