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Zamas Lam Introduction One of the main goals of in vitro species comparison studies is to assess whether there is adequate coverage from the preclinical species to humans with respect to disproportional and/or unique human metabolites. Traditionally, this is performed with liver microsomes or hepatocytes; however, these short-term in vitro systems do not usually provide multi-generation metabolites. In this study, we incubated selected compounds (, , and diclofenac) that have.

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