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Most frequently, the first sign is a single sore on the genitals, anus, or mouth. If left untreated, syphilis can progress to the second stage, which is characterized by a widespread rash. Pale round spots on the palms of the hands, soles of the feet, back, arms, and chest are a telltale sign of secondary syphilis.

About 15% to 30% of people infected with syphilis who don't get treatment will develop complications known as tertiary syphilis. In the late stage, the disease may damage the brain, nerves, eyes, heart, blood vessels, liver, bones and joints. These problems may occur many years after the original, untreated infection.

The late latent phase of syphilis occurs after 1 year of infection, and during this stage of the disease, infectious relapses are rare. Most patients who have not been treated remain in this late latent phase of the disease; however, about 30% go on to experience tertiary syphilis.

People who have had syphilis for a long time face serious health problems. Late stages of syphilis can cause tumors, blindness, and paralysis. It can damage your nervous system, brain and other organs, and may even kill you.

Tertiary Stage These include the heart and blood vessels, and the brain and nervous system. Tertiary syphilis is very serious and would occur 10–30 years after your infection began. In tertiary syphilis, the disease damages your internal organs and can result in death.

About 15% to 30% of people infected with syphilis who don't get treatment will develop complications known as tertiary syphilis. In the late stage, the disease may damage the brain, nerves, eyes, heart, blood vessels, liver, bones and joints. These problems may occur many years after the original, untreated infection.

Syphilis spreads from person-to-person by direct contact with a syphilitic sore, known as a chancre. Chancres can occur in, on, or around the , vagina, anus, rectum, and lips or mouth. Syphilis can spread during vaginal, anal, or oral sex.