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Clinicians should start with an initial dose of 2 mg/0.5 mg or 4 mg/1 mg /naloxone and may titrate upwards in 2 or 4 mg increments of , at approximately 2‐hour intervals, under supervision, to 8 mg/2 mg /naloxone based on the control of acute withdrawal symptoms.

In May of 2023, FDA approved Brixadi (Braeburn Inc.), a new dosage form of the partial opioid agonist .

The three-day rule permits practitioners to administer no more than one day's medication at a time for a maximum of three days, which cannot be renewed or extended. During the three-day period, the provider is expected to arrange for the patient's referral for treatment in a maintenance or detoxification program.

The final rule allows screening patients for initiation of via audio-only or audio-visual telehealth technology if certain providers determine that an adequate evaluation of the patient can, or has been, completed via telehealth.

The U.S. Food and Drug Administration (FDA) determined that the drug was not taken off the market because of concerns about safety or effectiveness. is still available in other parts of the world, and generic forms of sublingual are available in the United States.