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  • Pka Has A Critical Role In Synaptic Delivery Of Glur1- And Glur4 ... - Classic Jn Physiology

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J Neurophysiol 101: 2539 2549, 2009. First published March 4, 2009; doi:10.1152/jn.91282.2008. PKA Has a Critical Role in Synaptic Delivery of GluR1- and GluR4-Containing AMPARs During Initial Stages.

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AMPA receptors undergo fast, submillisecond activation by glutamate, leading to depolarization of the postsynaptic membrane and relief of magnesium block of NMDA receptors, followed by rapid desensitization and deactivation on a millisecond time scale (1).

Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions.

Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus.

receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons.

The role of a protein kinase is to transfer the γ-phosphate of magnesium adenosine triphosphate (MgATP) to other proteins. PKA phosphorylates serine and threonine residues; the tyrosine hydroxyl group is phosphorylated by a different enzyme.

Protein kinase A (PKA) is activated by the binding of cyclic AMP (cAMP), which causes it to undergo a conformational change.

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Contact Us
Delete My Account
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Industries
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Legal Guides
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All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
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Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
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airSlate WorkFlow
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Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232