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  • Pka Has A Critical Role In Synaptic Delivery Of Glur1- And Glur4 ... - Classic Jn Physiology

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J Neurophysiol 101: 2539 2549, 2009. First published March 4, 2009; doi:10.1152/jn.91282.2008. PKA Has a Critical Role in Synaptic Delivery of GluR1- and GluR4-Containing AMPARs During Initial Stages.

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AMPA receptors undergo fast, submillisecond activation by glutamate, leading to depolarization of the postsynaptic membrane and relief of magnesium block of NMDA receptors, followed by rapid desensitization and deactivation on a millisecond time scale (1).

Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions.

Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus.

receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons.

The role of a protein kinase is to transfer the γ-phosphate of magnesium adenosine triphosphate (MgATP) to other proteins. PKA phosphorylates serine and threonine residues; the tyrosine hydroxyl group is phosphorylated by a different enzyme.

Protein kinase A (PKA) is activated by the binding of cyclic AMP (cAMP), which causes it to undergo a conformational change.

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Name Change
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Small Business
Wills & Estates
Packages A-Z
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Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
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Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232