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  • The Essential Neutral Sphingomyelinase Is Involved In The Trafficking Of The Variant Surface

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Molecular Microbiology (2010) 76(6), 1461 1482 ? doi:10.1111/j.1365-2958.2010.07151.x First published online 15 April 2010 The essential neutral sphingomyelinase is involved in the traf?cking of the.

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The variant surface glycoprotein (VSG) coat covering the membrane of African trypanosomes protects them from lytic factors in human plasma and allows them to escape the host immune reaction.

(d) VSG switching can be mediated through transcriptional control whereby a previously silent ES is activated and the active ES is silenced. Pathogenic microorganisms employ numerous molecular strategies in order to delay or circumvent recognition by the immune system of their host.

VSG has played the role of a prototypical model protein for understanding the cell biology of the GPI anchor and the molecular genetics and immunology of antigenic variation, making it an exceptionally generous molecule, if at the same time sitting at the heart of a deadly immune evasion machine.

Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma. This genus is notable for their cell surface proteins. They were first isolated from Trypanosoma brucei in 1975 by George Cross.

The VSGs are long, rod-shaped homodimeric proteins of around 60kDa with two subdomains: a larger, N-terminal domain (NTD) of around 350-400 amino acids and a smaller 80-120 residue C-terminal domain (CTD) to which the GPI anchor is attached (Supplementary Data Fig. 1)8.

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Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
Privacy Notice
Legal Hub
Content Takedown Policy
Bug Bounty Program
About Us
Blog
Affiliates
Contact Us
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate WorkFlow
DocHub
Instapage
Social Media
Call us now toll free:
+1 833 426 79 33
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232