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  • Baseline Labial Salivary Gland Biopsy Results Form - Sicca

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Baseline Labial Salivary Gland Biopsy Results Form (BL) SICCA Study #021 Plate #120 Seq #003 Visit Date Participant ID # day month year Baseline Labial Salivary Gland Biopsy Results Form yes no 1.

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Minor salivary gland biopsy is an important technique that has been used for >50 years to assess for focal lymphocytic sialadenitis in patients suspected to have SS. Originally, this was performed by excising an elliptical segment of oral mucosa containing labial salivary gland tissue.

The diagnosis of Sjögren's syndrome (SS) in these patients is necessarily supported by a positive test for anti-Ro/SSA antibodies and/or a labial salivary gland biopsy showing focal lymphocytic sialadenitis with a focus score ≥1 (ie, "positive" lip biopsy).

Biopsies should be performed by individuals who are familiar with the lip biopsy procedures, this includes Oral Medicine specialists, and certain Oral Surgeons and Otolaryngologists (ENTs).

The skin or mucous membrane over the gland is cleaned with rubbing alcohol. A local pain-killing medicine (anesthetic) may be injected, and a needle is inserted into the gland. A piece of tissue or cells are removed and placed on slides. The samples are sent to the lab to be examined.

The biopsy site should be selected from the inner side of the lower lip, rich in minor salivary glands, avoiding the midline area due to its lesser content of glandular component (Fig.

An important method for establishing the diagnosis is to take a biopsy of the salivary glands in order to determine whether inflammation is present, and if so, its type and severity. The minor salivary glands just under the inner surface of the lip are the most accessible of these glands.

This minor procedure calls for removal of four or more salivary gland lobules through a small incision in the inner lip. A biopsy is considered to be positive if histopathologic analysis shows a focus score of greater than or equal to 1 per 4 mm2 of tissue (a focus is defined as a cluster of 50 or more lymphocytes).

Sjögren Syndrome Salivary gland biopsies show focal aggregates of lymphocytes, plasma cells, and macrophages; there may be larger foci with the appearance of germinal centers. This appearance is characteristic of chronic lymphocytic sialadenitis.

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232