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Y of Leipzig, Germany; 2Center for Advanced Research in Human Reproduction, Cleveland Clinic Foundation, Cleveland, OH, USA Poly-ADP-ribose polymerase-1 (PARP-1) is a DNA base excision repair enzyme. In somatic cells its nick sensor function is inactivated by caspase-3 during apoptosis. Data on PARP-1 presence and cleavage in human spermatozoa are conflicting. The aim of our study was to investigate the presence and cleavage of PARP-1 in ejaculated human spermatozoa using different western blo.

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