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What Is a Tissue Transglutaminase IgA (tTG-IgA) Test? A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease. In this autoimmune disorder, the immune system mistakenly thinks that gluten — a protein in wheat, barley, rye, and oats — is a foreign invader.

Optimal Result: 0 - 5 U/mL. Interpret your laboratory results instantly with us. A tissue transglutaminase IgA (tTg-IgA) test is used to help doctors diagnose celiac disease or to see how well people with the condition are doing.

Positive results for tissue transglutaminase (tTG) IgG antibodies are consistent with a diagnosis for celiac disease, particularly in individuals who are IgA deficient.

Positive tTG results may be seen in other autoimmune diseases, such as type 1 diabetes, autoimmune liver disease, autoimmune thyroid disease, and inflammatory bowel disease.

tTG IgA antibody concentrations greater than 40 U/mL usually correlate with results of duodenal biopsies consistent with a diagnosis of celiac disease.

tTG-IgA and tTG-IgG tests The tTG-IgA test is the preferred celiac disease serologic test for most patients. Research suggests that the tTG-IgA test has a sensitivity of 78% to 100% and a specificity of 90% to 100%.

What do the results mean? Negative. This means that celiac disease antibodies weren't found in your blood. ... Positive. This mean that celiac disease antibodies were found in your blood. ... Uncertain, indeterminate, or inconclusive. These terms all mean that it's unclear whether you have celiac disease.

Reference ranges: tTG ANTIBODY, IgA. <4.0 U/mL (negative) 4.0-10.0 U/mL (weak positive) >10.0 U/mL (positive)